Most relevant variables according to RF permutation index criterion for each type of data.

The permutation index reflects decreases in classification performance when the values of a given variable have been randomly permuted. Abnormalities refer to the presence of different lesions detected by reviewers (e.g. drusens, age-related macular degeneration features, etc. - see Table S1). ACCORD arm randomization refers to membership to one of the eights arms of the ACCORD trial.