Enrichment for enzymes and transporters in the NGT and IGT active module groups.

The FuncAssociate program [14] was used to identify enzymes and transporters that contributed a greater number of metabolites to the AMGs than expected by chance. Amino acid transporters with substrate profiles overlapping AMG metabolites organized in groups, with the transport system, AMG. substrates and mode of reaction (facilitated diffusion vs. exchange) and tissue distribution are indicated [22]. *Transporters/enzymes with padj<0.0125 (p<0.05 with Bonferonni correction for 4 AMGs experiments tested for enrichment). †transporters with padj = 0.0125–0.05.