Global DNA methylation pattern of fibroblasts in idiopathic pulmonary fibrosis: relationship to gene expression. Global DNA methylation pattern of fibroblasts in idiopathic pulmonary fibrosis: relationship to gene expression

Analysis of Idiopathic pulmonary fibrosis (IPF) at gene expression level. The hypothesis tested in the present study was that Epigenetic mechanisms are likely to be associated with pathogenesis in IPF. To determine the DNA methylation change, and their effects on gene expression, we compared microarray data of DNA methylation and RNA expression. Results provide that among the genes whose DNA methylation status and RNA expression were both significantly altered between IPF-rapid and normal controls. Overall design: Genomic DNA obtained from Idiopathic pulmonary fibrosis samples.