The Northern Sweden MONICA Study 1990

The Northern Sweden MONICA Study started with the WHO MONICA Study in 1985. The purpose was to monitor trends in mortality and morbidity in cardiovascular disease and relate them to trends in risk factors. Since 1985 21,000 strictly validated stroke events and 18,000 myocardial infarctions have been included in two registers. During the same period, six population based surveys have been taking place, the latest in 2009. The participation rates have been 69-81%. Subjects donated samples to the Northern Sweden Biobank. After 25 years since the start of the study, participants are starting to suffer from stroke, infarctions and diabetes in a rapidly increasing rate. We have successfully matched the event registers with population survey data, thereby creating a cost-effective prospective study design for MI, stroke and diabetes. Data from the three data bases has been used in more than 85 original studies and 14 dissertations since 2007. Increasingly other fields have been explored such as infectious diseases, nutrion and enviromental toxins. Purpose: To study cardiovascular risk factors in the population and the incidence of myocardial infarction and stroke after strict validation. A randomised sample of 2000 persons in ages 25-64 were invited to participate in the 1990 study.瑞典北部MONICA研究（Northern Sweden MONICA Study）起源于1985年启动的世界卫生组织MONICA研究（World Health Organization MONICA Study, WHO MONICA Study）。本研究旨在监测心血管疾病的死亡率与发病率变化趋势，并将其与危险因素的变化趋势相关联。自1985年以来，两个登记数据库已收录经严格验证的脑卒中事件21000例、心肌梗死事件18000例。同期共开展6项基于人群的调查，最新一项调查于2009年完成，调查参与率介于69%至81%之间。研究对象向瑞典北部生物样本库（Northern Sweden Biobank）捐献了生物样本。在研究启动25年后，研究参与者中脑卒中、心肌梗死与糖尿病的发病人数正快速攀升。我们已成功将事件登记数据与人群调查数据进行匹配，由此构建出针对心肌梗死（Myocardial Infarction, MI）、脑卒中与糖尿病的低成本前瞻性研究方案。自2007年以来，来自这三个数据库的数据已被应用于85项以上原创研究以及14篇学位论文。目前研究领域已逐步拓展，涵盖传染病、营养学与环境毒素等方向。 研究目标：在经过严格验证的前提下，探究人群中心血管疾病危险因素以及心肌梗死与脑卒中的发病情况。 1990年的研究共随机抽取2000名年龄介于25至64岁之间的人群作为研究对象并邀请其参与。