Additional file 2: of Association between polymorphisms in the GRIN1 gene 5′ regulatory region and schizophrenia in a northern Han Chinese population and haplotype effects on protein expression in vitro

Haplotypes formed by the seven SNPs in GRIN1 and disease risk (significance level = 0.025). Del-G-G represents the haplotype T-del-G-G-C-G-G, T-T-C represents the haplotype T-insT-T-G-C-C.The frequency distribution of haplotype T-del-G-G-C-G-G was significantly different between the case group and the control group, with p values of 0.005. Specifically, the frequency of haplotype T-del-G-G-C-G-G in the case group (77.8%) was much higher than in the control group (70.9%), increasing the disease risk (OR = 1.442, 95% CI: 1.116–1.862). Haplotype T-insT-T-G-C-G-C was not related to schizophrenia (XLSX 12 kb)

本数据集围绕GRIN1基因中7个单核苷酸多态性（Single Nucleotide Polymorphisms, SNPs）形成的单体型与疾病风险的关联展开分析，显著性水准设定为0.025。其中，Del-G-G代表单体型T-del-G-G-C-G-G，T-T-C代表单体型T-insT-T-G-C-C。单体型T-del-G-G-C-G-G的频率分布在病例组与对照组间存在显著差异，P值为0.005。具体而言，该单体型在病例组中的频率（77.8%）显著高于对照组（70.9%），可升高疾病发病风险（比值比OR=1.442，95%置信区间CI：1.116–1.862）。单体型T-insT-T-G-C-G-C与精神分裂症无显著关联（XLSX 12 kb）