Pairwise differences between ROC AUC curves and classification statistics in relation to hyperlipidemia in GLACIER (N = 1,257 for TC; N = 1,660 for TG).

NPV - negative predictive value; PPV - positive predictive value; ROC AUC - receiver operating characteristics area under the curve; TC - total cholesterol; TG - triglyceride.P values are calculated by a chi squared test comparing two ROC AUC curves.Model 1 = age,age2;sex,BMI; Model 2 = Model 1+ trait specific GRS; Model 3 = Model 1+ traditional risk factors (cholesterol intake, trans fat intake, saturated fat intake, carbohydrate intake, alcohol intake, physical activity); Model 4 = Model 1+ trait specific GRS + traditional risk factors.