Supplementary file 1_Hepatitis B Virus Infection Among Tribal Populations in India: A Systematic Review and Meta-Analysis.docx

ObjectivesThe introduction of the Hepatitis B virus (HBV) vaccine has significantly reduced the disease’s burden. Tribes comprise approximately 8.6% of the Indian population, making it pertinent to investigate the epidemiology of HBV among these individuals. We synthesized the prevalence of HBV among tribes in India.
MethodsWe searched the Medline (via the PubMed search engine), Embase, and CINAHL databases, in addition to the first 10 pages of Google Scholar. We included original observational studies that screened tribal populations for HBV infection, reported the prevalence of HBsAg (our main preference), and/or other markers. The risk of bias was assessed using the Appraisal Tool for Cross-Sectional Studies. The pooled prevalence was presented after conducting a meta-analysis (PROSPERO registration ID: CRD42022334938).
ResultsA total of 24 studies were selected for this study. The pooled prevalence of HBV (as measured by the proportion of individuals testing positive for hepatitis B surface antigen) was estimated to be 9.99% (95% confidence interval (CI) 6.07–14.75, I2 = 98.7%, p < 0.01). The highest HBV prevalence was noted in the northern zone of the country (19.60%, 95% CI 15.09–24.54, I2 = 84.4%, p < 0.01), followed by the northeastern zone (13.43%, 95% CI 6.09–23.08, I2 = 98.4%, p < 0.01), and the southern zone (10.44%, 95% CI 4.75–18.01, I2 = 98.9%, p < 0.01).
ConclusionA considerable prevalence of HBV was observed in tribal communities in India, a fact that cannot be overlooked. This information may be useful for planning HBV vaccination strategies among tribes in India.