Morphological Observation of Polylactide-b-Poly (Ethylene Glycol)-bPolylactide Triblock Copolymers Stereocomplex Films

The objectives of this work were to prepare PLLA-PEG-PLLA/PDLA-PEG-PDLA blend films with and without tetracycline by solvent casting method and to observe their morphology drug under the scanning electron microscope (SEM). The results found that film prepared from pure PLLA-PEG-PLLA had smooth surfaces but composed of some small pores with tetracycline. The PLLA-PEG-PLLA/PDLAPEG-PDLA blend films showed varied in surfaces and textures depending on the PDLA-PEG-PDLA ratios used. All blend films had small pores on their surfaces but still had homogeneous texture. The number of pores smooth and dense texture of the blend films were gradually increased when the ratio of PDLA-PEGPDLA increased. This confirmed that stereocomplexation formation between both copolymers. The obtained results indicated the potential of blend films for drug delivery system development.