Supplementary Material for: Ambient Temperature and Severity of Intracerebral Haemorrhage: The INTERACT1 Study

<b><i>Background:</i></b> Intracerebral haemorrhage (ICH) rates increase in winter months. We aimed to determine associations of ambient temperature with clinical severity and haematoma size in acute ICH among Chinese participants in the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT1). <b><i>Methods:</i></b> INTERACT1 was a randomised controlled trial of early intensive blood pressure lowering in 404 patients with acute ICH. Among 304 (79%) Chinese participants, data on ambient temperature (average, minimum, maximum and range) on the day of ICH onset obtained from the China Meteorological Data Sharing Service System were linked to measures of clinical severity: elevated National Institute of Health Stroke Scale score (&gt;10), low Glasgow Coma Scale score (&lt;14), and haematoma parameters at the time of presentation. Clinical outcomes were evaluated in logistic regression models, and haematoma volume (log transformed, with and without intraventricular haemorrhage, IVH) was evaluated in multivariable regression models. <b><i>Results:</i></b> No significant associations were evident between temperature parameters and clinical parameters and haematoma volume (with and without IVH), even after adjustment for key prognostic factors. <b><i>Conclusions:</i></b> No relationship was evident between ambient temperature and severity in acute ICH.

<b><i>背景:</i></b> 脑出血（Intracerebral haemorrhage, ICH）的发病率在冬季有所升高。本研究旨在明确急性脑出血强化降压试验（Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial, INTERACT1）中中国受试者的环境温度与急性脑出血临床严重程度及血肿体积的关联。<b><i>方法:</i></b> INTERACT1是一项针对404例急性脑出血患者实施早期强化降压治疗的随机对照试验。在其中304例（占比79%）中国受试者中，将从中国气象数据共享服务系统获取的脑出血发病当日的环境温度数据（包括日均温、最低温、最高温及气温日较差），与多项临床严重程度评估指标进行关联分析：美国国立卫生研究院卒中量表（National Institute of Health Stroke Scale, NIHSS）评分升高（＞10分）、格拉斯哥昏迷量表（Glasgow Coma Scale, GCS）评分降低（＜14分），以及就诊时的血肿相关参数。采用逻辑回归模型评估临床结局，采用多变量回归模型分析血肿体积（经对数转换，伴或不伴脑室出血intraventricular haemorrhage, IVH）。<b><i>结果:</i></b> 即便在校正了关键预后因素后，环境温度参数与临床指标及血肿体积（伴或不伴IVH）之间均未发现显著关联。<b><i>结论:</i></b> 环境温度与急性脑出血的严重程度之间未发现明确关联。