Kinetic Resolution of Axially Chiral 5- or 8‑Substituted Quinolines via Asymmetric Transfer Hydrogenation

An
efficient kinetic resolution of axially chiral 5- or 8-substituted
quinoline derivatives was developed through asymmetric transfer hydrogenation
of heteroaromatic moiety, simultaneously obtaining two kinds of axially
chiral skeletons with up to 209 of selectivity factor. This represents
the first successful application of asymmetric transfer hydrogenation
of heteroaromatics in kinetic resolution of axially chiral biaryls.