Homo sapiens Genome sequencing

Splicing factor proline and glutamine rich (SFPQ), also known as polypyrimidine tract-binding protein-associated splicing factor (PSF), is a nuclear multifunctional protein. SFPQ is involved in various biological processes, including paraspeckle formation, miRNA synthesis and specially in transcription regulation. In addition, SFPQ is involved in the innate immune response to viruses. Studies have showed that SFPQ increase the viral replication-cycle of hepatitis delta-virus by binding its viral RNA. In addition, SFPQ promote influenza A virus transcription and post-transcriptional processing such as mRNA polyadenylation. We investigated the effects of SFPQ on gene transcription regulation by RNA-seq and then provided clues to explore whether SFPQ is involved in EMCV infection.