mRNA profiling of injured mouse livers with MycER activation

This study explore the role of the Myc oncogene in liver injury, in particular for the determination of the cellular programme involved in tissue repair and normalization after injury, a process that is blocked by Myc deregulation. The first objective of this study is to define the transcriptional profile of mouse livers 12 days after injury with or without MycER activation. The second objective is to determine the trancriptionl signature at 1,2,3,7 days after MycER was inactivated in pre injured liver to monitor its normalization. Overall design: 3 mice per time points where used. The first analysis is done comparing samples "12" with "12ON", for the second ojective the 4 OFF time points (1,2,3,7) where compared to the "12ON" samples.