Mining Plants for Bacterial Quorum Sensing Modulators

The
bacterial plant pathogen Agrobacterium tumefaciens uses quorum sensing (QS) in order to regulate the transfer of DNA
into the host plant genome, and this results in the induction of crown
gall tumors. The deleterious results of these infections are widespread
and affect many species of fruit and crops. In order to further our
understanding of this process and to provide potential solutions,
we evaluated a library of 3800 natural products from plant sources
and identified potent compounds that are able to strongly modulate
plant–bacterial interactions.