Identification of heterogeneous senescence-associated transcriptional programs. Identification of heterogeneous senescence-associated transcriptional programs

We set out to characterize the transcriptional heterogeneity of the senescence program using a large number of whole-transcriptome sequencing datasets generated by us or publicly available. We identify a number of senescence transcriptional signatures associated to specific stresses or cell types. We also merge all the studies to identify and validate the genes that are universally differentially regulated during senescence.