Crystal structure of BACE1 in complex with hydroxyethylamine-macrocyclic inhibitor 19
收藏Protein Data Bank Japan2024-11-20 更新2026-03-21 收录
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Crystal structure of BACE1 in complex with hydroxyethylamine-macrocyclic inhibitor 19 Descriptor: (12S)-12-[(1R)-2-{[(4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl]amino}-1-hydroxyethyl]-1,13-diazatricyclo[13.3.1.1~6,10~]icosa-6(20),7,9,15(19),16-pentaene-14,18-dione, Beta-Secretase 1, GLYCEROL, ... Authors: Whittington, D.A, Long, A.M, Li, V. Deposit date: 2013-04-25 Release date: 2013-07-03 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Hydroxyethylamine-based inhibitors of BACE1: P1-P3 macrocyclization can improve potency, selectivity, and cell activity. Bioorg.Med.Chem.Lett., 23, 2013
创建时间：
2013-04-25
