Transcriptomic profile of YB-1 regulated downstream targets in LNCaP prostate cancer cells

The transcription factor and RNA-interacting Y-box binding protein-1 (YB-1 protein, YBX1 gene) has gained interest as a prognostic biomarker and therapeutic target in various malignancies including prostate cancer. Using a custom prostate-cancer-focussed microarray platform, we have established a transcriptome-wide profile of YB-1 target transcripts in the androgen sensitive prostate cancer cell line LNCaP, including RNAs regulated by YB-1 at the transcriptional and post-transcriptional level; under standard culture conditions (FBS), in androgen deprived culture conditions (CSS) and following stimulation with dihydrotestosterone (DHT). This SuperSeries is composed of the SubSeries listed below. The project consists of 3 data sets / SubSeries that were processed and analysed separately. Each data set was derived from 3-4 independent biological repeats for each sample group. Refer to individual Series