Additional file 1: of Role of miR-146a in neural stem cell differentiation and neural lineage determination: relevance for neurodevelopmental disorders

Table S1. Detailed information of all patients and controls whose brain samples were used in this study. Table S2. Possibly deleterious variants in known ASD and ID genes. Table S3. DEGs identified in undifferentiated cells. Table S4. DEGs identified in differentiated cells. Table S5. Validation of RNA-Seq using RT-qPCR on Fluidigm array. Table S6. Top 20 cannonical pathways deregulated in undifferentiated cells. Table S7. Top 4 nodes enriched for protein-protein interaction as calculated by ClusterOne Plugin. Table S8. Top 20 cannonical pathways deregulated in the cell cycle modules of differentiated cells. Table S9. Top 20 cannonical pathways deregulated in the cell neuronal modules of differentiated cells. Table S10. Cell type enrichment analysis of DEGs from the Cell Cycle and Neuronal Modules. (XLSX 888 kb)

补充表S1：本研究中使用脑样本对应的所有患者与对照的详细信息。
补充表S2：已知自闭症谱系障碍（ASD, Autism Spectrum Disorder）和智力障碍（ID, Intellectual Disability）基因中的潜在有害变异。
补充表S3：未分化细胞中鉴定得到的差异表达基因（DEGs, Differentially Expressed Genes）。
补充表S4：分化细胞中鉴定得到的差异表达基因。
补充表S5：采用实时定量聚合酶链反应（RT-qPCR, Reverse Transcription Quantitative Polymerase Chain Reaction）结合Fluidigm芯片（Fluidigm array）对RNA测序（RNA-Seq, RNA Sequencing）结果进行验证的相关数据。
补充表S6：未分化细胞中失调的前20条经典通路。
补充表S7：通过ClusterOne插件计算得到的、富集蛋白质-蛋白质相互作用的前4个节点。
补充表S8：分化细胞的细胞周期模块中失调的前20条经典通路。
补充表S9：分化细胞的神经元模块中失调的前20条经典通路。
补充表S10：取自细胞周期与神经元模块的差异表达基因的细胞类型富集分析。（XLSX 888 KB）