通过上转换光遗传学纳米系统对泛素介导的蛋白质降解的时空调控

蛋白质降解技术是调节细胞生命活动最直接、最有效的方式之一，有望应用于各种疾病的治疗。然而，目前的蛋白质降解技术，如一些小分子降解剂，无法实现时空调控，难以转化为临床应用。数据集来自于稀土发光检测与应用新技术研究，其中包含一种上转换光遗传学纳米系统介导的特异性蛋白质降解测试的数据。实验研究中，细胞在通过转换光遗传学纳米系统响应近红外光，触发泛素蛋白酶体途径。所述数据通过光纤光谱仪（AvaSpecULS2048-USB2，Avantes）采集获得，采集时间为2019年6月16日，采集地点为天津大学。数据体量约为50 kB。

Protein degradation technology is one of the most direct and effective approaches to regulate cellular life activities, and holds great promise for the treatment of various diseases. However, current protein degradation technologies, such as certain small-molecule degraders, fail to achieve spatiotemporal regulation, making it difficult to translate them into clinical applications. This dataset is derived from the research on new technologies for rare-earth luminescence detection and applications, and contains data from specific protein degradation assays mediated by an upconversion optogenetic nanosystem. In the experimental studies, cells respond to near-infrared light via the upconversion optogenetic nanosystem, thereby triggering the ubiquitin-proteasome pathway. The aforementioned data were collected using a fiber optic spectrometer (AvaSpecULS2048-USB2, Avantes) on June 16, 2019, at Tianjin University. The total data volume is approximately 50 kB.

搜集汇总

背景与挑战

背景概述

该数据集聚焦于利用上转换光遗传学纳米系统实现泛素介导的蛋白质降解的时空调控，以解决当前蛋白质降解技术难以精准调控的问题。数据来源于2019年6月16日在天津大学通过光纤光谱仪采集的实验测试结果，体量约为50 kB，涉及稀土发光检测与应用新技术研究。