Transcriptomic analyses of the effects of hepatic insulin signaling on hepatic gene expression in the PiZ mouse model of alpha-1-antitrypsin deficiency liver disease

RNA-Seq data on livers from 4-5 month old male PiZ mice with or without genetic disruption of insulin receptor and FOXO1 hepatic expression Analyses of WT, Z, and ZZ mice, WT v LIRKO v LIRKO-FOXO1-KO本数据集为4-5月龄雄性PiZ小鼠的肝脏组织RNA测序（RNA-Seq）数据，受试小鼠存在或不存在胰岛素受体（insulin receptor）与肝内FOXO1表达的基因敲除处理。本研究对野生型（WT）、Z型及ZZ型小鼠开展转录组分析，并进行野生型（WT）、肝脏特异性胰岛素受体敲除（LIRKO）与肝脏特异性胰岛素受体-FOXO1双敲除（LIRKO-FOXO1-KO）三组间的比较。