Dataset on the effect of vancomycin on the gut microbiome in normal control mice

Here we treated normal control (CON) mice with vancomycin (Vanc) to disturb the gut microbiota. In order to examine the gut microbial changes, we used a 16S rRNA gene sequencing approach to analyze the gut microbiome in caecum contents of normal control (CON) and vancomycin-treated normal control (CONV) mice at 3, 7 and 11 weeks.<br> This study is submitted to Microbiome. Hong Zheng, Pengtao Xu, Qiaoying Jiang, Qingqing Xu, Yafei Zheng, Junjie Yan, Hui Ji, Jie Ning, Xi Zhang, Chen Li, Limin Zhang, Yuping Li, Xiaokui Li, Weihong Song, and Hongchang Gao. (2021). Depletion of acetate-producing bacteria from the gut microbiota facilitates cognitive impairment through the gut-brain neural mechanism in diabetic mice.

本研究使用万古霉素（vancomycin, Vanc）处理正常对照（normal control, CON）小鼠，以扰乱其肠道菌群。为探究肠道菌群的变化特征，我们采用16S rRNA基因测序（16S rRNA gene sequencing）技术，对3周、7周及11周龄的正常对照（CON）小鼠与经万古霉素处理的正常对照（CONV）小鼠的盲肠内容物进行肠道微生物组（gut microbiome）分析。本研究已投稿至《Microbiome》期刊，作者团队包括Hong Zheng、Pengtao Xu、Qiaoying Jiang、Qingqing Xu、Yafei Zheng、Junjie Yan、Hui Ji、Jie Ning、Xi Zhang、Chen Li、Limin Zhang、Yuping Li、Xiaokui Li、Weihong Song与Hongchang Gao，该研究于2021年发表，题为《肠道菌群中产乙酸菌的耗竭通过肠-脑神经机制（gut-brain neural mechanism）加剧糖尿病小鼠的认知损伤》。