Supplementary data - numerical values from A diabetes-like biochemical and behavioural phenotype of <i>Drosophila</i> induced by predator stress

Predation can have both lethal and non-lethal effects on prey. The nonlethal effects of predation can instil changes in prey life history, behaviour, morphology and physiology, causing adaptive evolution. The chronic stress caused by sustained predation on prey is comparable to chronic stress conditions in humans. Conditions like anxiety, depression, and posttraumatic stress syndrome have also been implicated in the development of metabolic disorders such as obesity and diabetes. In this study, we found that predator stress induced during larval development in fruit flies <i>Drosophila melanogaster</i> impairs carbohydrate metabolism by systemic inhibition of Akt protein kinase, which is a central regulator of glucose uptake. However, <i>Drosophila</i> grown with predators survived better under direct spider predation in the adult phase. Administration of metformin and 5-hydroxytryptophane (5-HTP), a precursor of the neurotransmitter serotonin, reversed these effects. Our results demonstrate a direct link between predator stress and metabolic impairment, suggesting that a diabetes-like biochemical phenotype may be adaptive in terms of survival and reproductive success. We provide a novel animal model to explore the mechanisms responsible for the onset of these metabolic disorders that are highly prevalent in human populations.

捕食作用对猎物兼具致死与非致死效应。捕食的非致死效应可诱导猎物在生活史、行为、形态与生理层面发生改变，进而引发适应性进化。持续捕食给猎物带来的慢性应激，可与人类的慢性应激状态相类比。焦虑、抑郁、创伤后应激综合征等病症，也被发现与肥胖、糖尿病等代谢紊乱的发生存在关联。本研究发现，在黑腹果蝇（Drosophila melanogaster）幼虫发育期施加的捕食者应激，会通过系统性抑制Akt蛋白激酶（Akt protein kinase）——该激酶是葡萄糖摄取的核心调控因子——损害碳水化合物代谢。然而，与捕食者共同饲养的果蝇，在成虫阶段遭遇蜘蛛直接捕食时存活率更高。施用二甲双胍（metformin）与5-羟色氨酸（5-hydroxytryptophane，5-HTP，神经递质血清素的前体）可逆转上述效应。本研究结果证实了捕食者应激与代谢损伤之间存在直接关联，提示类似糖尿病的生化表型或许在生存与繁殖成功层面具有适应性意义。我们构建了一种全新的动物模型，用于探究在人类群体中高发的这类代谢紊乱的发病机制。

搜集汇总

背景与挑战

背景概述

该数据集是《捕食者压力诱导果蝇糖尿病样生化表型》研究的补充数值数据，以.xlsx格式提供原始数据。研究揭示捕食者压力通过抑制Akt蛋白激酶导致果蝇代谢紊乱，但成年期存活率提高，并验证了二甲双胍和5-HTP的逆转效应，为人类代谢疾病研究提供了新型动物模型。