cyp_p450_1a2_inhibition_veith_et_al

## Dataset Details

### Dataset Description

The CYP P450 genes are involved in the formation and breakdown (metabolism)
of various molecules and chemicals within cells. Specifically, CYP1A2 localizes
to the endoplasmic reticulum and its expression is induced by some polycyclic
aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. It
is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic
substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen.

- **Curated by:**
- **License:** CC BY 4.0

### Dataset Sources

- [corresponding publication](https://doi.org/10.1038/nbt.1581)
- [data source](https://tdcommons.ai/single_pred_tasks/adme/#cyp-p450-1a2-inhibition-veith-et-al)

## Citation

**BibTeX:**

```bibtex
@article{Veith2009,
doi = {10.1038/nbt.1581},
url = {https://doi.org/10.1038/nbt.1581},
year = {2009},
month = oct,
publisher = {Springer Science and Business Media LLC},
volume = {27},
number = {11},
pages = {1050--1055},
author = {Henrike Veith and Noel Southall and Ruili Huang and Tim James
and Darren Fayne and Natalia Artemenko and Min Shen and James Inglese
and Christopher P Austin and David G Lloyd and Douglas S Auld},
title = {Comprehensive characterization of cytochrome P450 isozyme selectivity
across chemical libraries},
journal = {Nature Biotechnology}
```

## 数据集详情

### 数据集描述
细胞色素P450（CYP P450）基因参与细胞内多种分子与化学物质的合成与分解（代谢）过程。其中，CYP1A2亚型定位于内质网，其表达可被某些多环芳烃（PAHs）诱导，而部分此类多环芳烃存在于香烟烟雾中。该酶可将部分多环芳烃代谢为致癌中间产物。该酶的其他外源性底物包括咖啡因、黄曲霉毒素B1（aflatoxin B1）以及对乙酰氨基酚（acetaminophen）。

- **整理方：**
- **授权协议：** CC BY 4.0

### 数据集来源
- [相关研究论文](https://doi.org/10.1038/nbt.1581)
- [数据源](https://tdcommons.ai/single_pred_tasks/adme/#cyp-p450-1a2-inhibition-veith-et-al)

## 引用信息

**BibTeX格式引用：**
bibtex
@article{Veith2009,
doi = {10.1038/nbt.1581},
url = {https://doi.org/10.1038/nbt.1581},
year = {2009},
month = oct,
publisher = {施普林格科学与商业媒体有限公司},
volume = {27},
number = {11},
pages = {1050--1055},
author = {Henrike Veith and Noel Southall and Ruili Huang and Tim James
and Darren Fayne and Natalia Artemenko and Min Shen and James Inglese
and Christopher P Austin and David G Lloyd and Douglas S Auld},
title = {化学文库跨细胞色素P450同工酶选择性的全面表征},
journal = {《自然·生物技术》(Nature Biotechnology)}
}