Dataset from A Randomized, Double-blind, Multicenter, Active-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Fixed Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Subjects With Treatment-resistant Depression

The purpose of this study is to compare the efficacy and safety of switching
treatment-resistant depression (TRD) participants from a prior antidepressant treatment (to
which they have not responded) to either intranasal esketamine plus a new oral antidepressant
or switching to a new oral antidepressant plus intranasal placebo.