Genome-wide survey of c-Myc targets in chicken skeletal muscle cells by high-throughput sequencing. Gallus gallus breed:Xinghua chicken

By applying ChIP-seq, we generated genome-wide maps of c-Myc in skeletal myoblasts and myotubes. We found that c-Myc binds to 19354 confident targets with a large portion residing in the intergenic regions. In addition, c-Myc was found to regulate many loci. Further detailed study revealed that YY1 can regulate many genes, miRNAs, and lincRNAs, which are fucntional in skeletal myogenesis.