Comparisons between the aggregation parameters in different populations.

The distributions of the aggregation parameter values of the analyzed population are compared to the ones of the reference population using statistical tests (see Methods).+++ and ??? indicate that the analyzed population has a distribution significantly (pn.s., the distributions of the analyzed and reference populations are not significantly different (p>0.05).aThe results remain unchanged when the sequences without signal peptides of the corresponding subcellular districts (membrane proteins excluded) are compared with a reference database composed of all the human non-membrane protein sequences without the identified signal peptides.bProteins forming amyloid fibrils and intracellular inclusions with amyloid-like characteristics.cThe distributions of the two populations differ significantly although their median values are not significantly different (significant differences in the Kolmogorov-Smirnov test and not in the Mann-Whitney test).dThe difference was significant in the Mann-Whitney test but not in the Kolmogorov-Smirnov test (parameter lacking a defined distribution).