Supplementary Material for: A Systematic Review and Meta-Analysis of the Effectiveness of Acetylcholinesterase Inhibitors and Memantine in Treating the Cognitive Symptoms of Dementia

<b><i>Background:</i></b> Acetylcholinesterase inhibitors (AChEIs) and memantine are commonly used in the management of dementia. In routine clinical practice, dementia is often monitored via the Mini-Mental State Examination (MMSE). We conducted a systematic review and meta-analysis of the effects of these drugs on MMSE scores. <b><i>Summary:</i></b> Eighty trials were identified. Pooled effect estimates were in favour of both AChEIs and memantine at 6 months. Meta-regression indicated that dementia subtype was a moderator of AChEI treatment effect, with the effect of treatment versus control twice as high for patients with Parkinson disease dementia/ dementia with Lewy bodies (2.11 MMSE points at 6 months) as for patients with Alzheimer disease/vascular dementia (0.91 MMSE points at 6 months). <b><i>Key Messages:</i></b> AChEIs demonstrate a modest effect versus control on MMSE scores which is moderated by dementia subtype. For memantine the effect is smaller.

<b><i>背景：</i></b> 乙酰胆碱酯酶抑制剂（Acetylcholinesterase inhibitors, AChEIs）与美金刚（memantine）是临床常用的痴呆治疗药物。在常规临床实践中，医护人员通常通过简易精神状态检查表（Mini-Mental State Examination, MMSE）对痴呆患者的病情进行监测。本研究针对上述两类药物对MMSE评分的影响开展了系统综述与荟萃分析。<b><i>摘要：</i></b> 本研究共纳入80项临床试验。合并效应量分析结果显示，在用药6个月时，乙酰胆碱酯酶抑制剂和美金刚均展现出积极的治疗效果。荟萃回归分析表明，痴呆亚型是乙酰胆碱酯酶抑制剂治疗效应的调节变量：帕金森病痴呆/路易体痴呆患者的治疗组与对照组间的效应量是阿尔茨海默病/血管性痴呆患者的2倍（前者用药6个月后MMSE评分提升2.11分，后者提升0.91分）。<b><i>核心结论：</i></b> 乙酰胆碱酯酶抑制剂相较于对照组对MMSE评分仅存在轻度改善作用，且该效应受痴呆亚型的调节；美金刚的改善效应则更为微弱。