Macrophage depletion in rat inflamed knees prevents the activation of synovial mesenchymal stem cells via weakened Nampt and Spp1 signaling. Macrophage depletion in rat inflamed knees prevents the activation of synovial mesenchymal stem cells via weakened Nampt and Spp1 signaling

To analyze the crosstalk between synovial MSCs and macrophages, we conducted scRNA-seq for synovium. Overall design: Synovial tisuues collected from inflamed rat knees treated with control liposomes or clodronate liposomes were subjected to scRNA-seq.