The proportion of substitutions with ΔΔG within a stability zone around zero and the associated p-values.

Stability zone defined in the left column. The top row within each stability zone shows the accessible substitutions against which the other sets are compared. For ΔΔGfold, ΔΔGbind, and ΔΔGfold & ΔΔGbind together, the left column gives the proportion of substitutions in the stability zone with the actual number in parentheses. The right column gives the p-value associated with the null hypothesis that the observed counts (experimental, wild, and experimental + wild rows) are random samples from the accessible set and fall in the stability zone by chance. By ΔΔGfold & ΔΔGbind we mean the substitutions observed jointly within the zone by both measures of stability. Test are all two-sided and based on 10,000 random samples of accessible set.The proportion of substitutions with ΔΔG within a stability zone around zero and the associated p-values.