Gene expression changes of p-nitroanisole-induced in renal cortex of rats

This study is to develop a short term and highly accurate prediction method of renal carcinogenicity based on gene expression profile of rats administrated by carcinogens. We conducted 28 days-repeated dose experiments in male SD rats with p-nitroanisole, and the gene expression profiles of renal cortex were analyzed using custom microarrays.本研究旨在开发一种基于致癌物染毒大鼠基因表达谱的短期高精度肾脏致癌性预测方法。本研究采用对硝基茴香醚（p-nitroanisole）对雄性SD大鼠开展28天重复给药实验，并利用定制微阵列（custom microarrays）分析大鼠肾皮质的基因表达谱。