Usp7 regulates the developmental progression of the morula-to-blastocyst transition via deubiquitination of Yap. Mus musculus strain:not applicable | isolate:not applicable | breed:Kunming | cultivar:not applicable

Preimplantation embryos undergo a series of important biological events, including epigenetic reprogramming and lineage differentiation, and the key genes and specific mechanisms that regulate these events are critical to reproductive success. USP7 is a deubiquitinase. It has been reported that USP7 is involved in the regulation of various cellular activities. Although USP7 has multiple functions, its role and mechanism in mammalian preimplantation embryo development remains unknown.