Genome-wide chromatin and gene expression profiling during memory formation and maintenance in adult mice. [Data Record 5: CRMs]

<b>DESCRIPTION</b><br>Neuronal and non-neuronal cis-regulatory modules in tissues ACC and CA1 were predicted, together with their activity, using a discriminative random forest classifier RFECS that was trained on a published set of positive and negative transcription factor binding sites and histone post-translational modifications.<br><br><b>DATA REPOSITORIES<br></b>EPIGENOME BROWSER (https://memory-epigenome-browser.dzne.de/)<br>Contains the visualisation tracks for the CRMs (i.e. positions of CRMs) under category "ENHANCER-DATA". Sample names include cell-type (NonNeuron or Neuron) and tissue (ACC or CA1) separated by dashes. GFF files can also be downloaded for local visualisation.<br>Figshare<br>The tables here contain all predicted cis-regulatory modules for each cell-type and tissue combination, where each table includes the CRM coordinates and the RFECS probabilities for each CRM.<br><br><b>DATA GENERATION</b><br>The binary file containing the RFECS trained forest used for the CRM predictions can be found in Figshare (https://dx.doi.org/10.6084/m9.figshare.3153406), and a clarification on how to run the analysis can be found in the reference mentioned below.<br><br>

<b>数据集描述</b>
针对组织ACC与CA1中的神经元及非神经元顺式调控模块（cis-regulatory modules）及其调控活性进行了预测，所用方法为基于已发表的正负转录因子结合位点（transcription factor binding sites）与组蛋白翻译后修饰（histone post-translational modifications）数据集训练得到的判别式随机森林分类器RFECS。

<b>数据资源库</b>
表观基因组浏览器（EPIGENOME BROWSER，https://memory-epigenome-browser.dzne.de/）
该平台在"ENHANCER-DATA"分类下提供顺式调控模块的可视化轨道（即顺式调控模块的位置信息）。样本名称以连字符分隔，分别包含细胞类型（NonNeuron或Neuron）与组织类型（ACC或CA1）。用户亦可下载GFF格式文件用于本地可视化分析。
Figshare
该平台上传的表格涵盖了所有细胞类型-组织组合下的预测顺式调控模块，每张表格均包含顺式调控模块的坐标信息以及各模块的RFECS预测概率。

<b>数据生成</b>
用于顺式调控模块预测的、已训练完成的RFECS分类器二进制文件可于Figshare平台（https://dx.doi.org/10.6084/m9.figshare.3153406）获取，分析流程的详细说明可参见下文参考文献。