Data from: Prevalence characteristics of cervical human papillomavirus (HPV) genotypes in the Taizhou area, China: a cross-sectional study of 37 967 women from the general population

Objectives: High-risk human papillomaviruses (hrHPVs) are highly prevalent worldwide, and HPV genotypes differ between geographical regions; however, sexually transmitted HPV may lead to cervical carcinogenesis. The objective of this cross-sectional study was to estimate the prevalence characteristics of cervical HPV genotypes in Taizhou, Southeast China.

Setting and participants: A population-based sample of 37 967 eligible women (median age: 41.6; range: 15–90 years) visiting the Taizhou ENZE Medical Center in Taizhou (2012–2016) was analysed. HPV genotyping was performed on the collected specimens using a GP5+/bioGP6+-PCR/MPG assay by Luminex 200, which simultaneously identifies 27 different HPV genotypes and the β-globin gene (internal control).

Results: The overall HPV infection rate was 22.8% in the Taizhou-based population, and the prevalence of high-risk HPV, low-risk HPV and mixed high-risk and low-risk HPV infection was 14.2%, 5.7% and 3.0%, respectively. The most prevalent genotypes were HPV52 (19.7%), 16 (11.9%), 58 (11.5%), 39 (7.2%), 18 (6.6%) and 56 (5.6%). The rate of multiple-type HPV infection was 5.7% in the whole population, and the HPV52+58, HPV16+52 and HPV16+18 mixed genotypes were most common in women with multiple infections. The age-specific HPV prevalence showed a bimodal curve, with a first peak below the age of 21 years (41.6%), followed by a second peak in the age group of 56–60 years (28.5%). Moreover, the HPV infection rate differed significantly between the outpatient and physical examination groups (24.0% vs 19.5%, p<0.0001). Further data comparisons showed that the distribution of HPV genotypes varied markedly between the two groups.

Conclusions: Data from this study could be valuable for HPV-based cervical cancer screening efforts in certain areas, support the local vaccination programme in the Taizhou region and facilitate future diagnosis and treatment of HPV diseases.

研究目的：高危型人乳头瘤病毒（high-risk human papillomaviruses, hrHPVs）在全球范围内流行率极高，且不同地理区域的HPV基因型存在差异；经性传播的HPV可诱发宫颈癌变。本横断面研究（cross-sectional study）旨在明确中国东南部台州地区宫颈HPV基因型的流行特征。

研究对象与研究场景：本研究分析了2012-2016年间就诊于台州恩泽医疗中心的37967名符合纳入标准的女性，其年龄中位数为41.6岁，年龄范围为15~90岁。采用Luminex 200平台，通过GP5+/bioGP6+-PCR/MPG检测法对采集的标本进行HPV基因分型，该方法可同时鉴定27种不同的HPV基因型及β-珠蛋白基因（内参对照）。

研究结果：台州地区人群总体HPV感染率为22.8%，其中高危型HPV、低危型HPV以及高危与低危型混合感染的检出率分别为14.2%、5.7%和3.0%。最常见的HPV基因型依次为HPV52（19.7%）、HPV16（11.9%）、HPV58（11.5%）、HPV39（7.2%）、HPV18（6.6%）及HPV56（5.6%）。全人群多重HPV感染率为5.7%，其中以HPV52+58、HPV16+52及HPV16+18混合型基因型最为多见。按年龄分组的HPV感染率呈双峰分布：21岁以下人群出现第一感染高峰（41.6%），随后在56~60岁年龄组出现第二高峰（28.5%）。此外，门诊组与体检组的HPV感染率存在显著差异（24.0% vs 19.5%，p<0.0001），进一步分析显示两组的HPV基因型分布亦存在显著差异。

研究结论：本研究数据可为特定区域基于HPV检测的宫颈癌筛查工作提供参考，助力台州地区当地疫苗接种计划的开展，并为未来HPV相关疾病的诊疗工作提供支持。