Comparative study of peritoneal adhesions after intraperitoneal implantation in rats of meshes of polypropylene versus polypropylene/polyglecaprone versus polyester/porcine collagen

Abstract Purpose To Compare the extent and intensity of adhesions formed between the intra-abdominal organs and the intraperitoneal implants of polypropylene mesh versus polypropylene/polyglecaprone versus polyester/porcine collagen used for correction of abdominal wall defect in rats. Methods After the defect in the abdominal wall, thirty Wistar rats were placed in three groups (ten animals each) for intraperitoneal mesh implant: polypropylene group, polypropylene/polyglecaprone group, and polyester/porcine collagen group. The macroscopic evaluation of the extent and intensity of adhesions was performed 21 days after the implant. Results The polypropylene group had a higher statistically significant impairment due to visceral adhesions (p value = 0.002) and a higher degree of intense adherence in relation to polypropylene/polyglecaprone and polyester/porcine collagen groups (p value<0.001). The polyester/porcine collagen group showed more intense adhesions than the polypropylene/polyglecaprone group (p value=0.035). Conclusions The intraperitoneal implantation of polypropylene meshes to correct defects of the abdominal wall caused the appearance of extensive and firm adhesions to intra-abdominal structures. The use of polypropylene/polyglecaprone or polyester/porcine collagen tissue-separating meshes reduces the number and degree of adhesions formed.

【摘要】目的 比较用于修复大鼠腹壁缺损的三种腹腔内植入材料——聚丙烯（polypropylene）网片、聚丙烯/聚卡普隆（polypropylene/polyglecaprone）网片以及聚酯/猪胶原蛋白（polyester/porcine collagen）网片，所引发的腹腔内脏器与植入物之间粘连的范围与强度。方法 构建大鼠腹壁缺损模型后，将30只Wistar大鼠随机分为3组（每组10只）实施腹腔内网片植入：聚丙烯组、聚丙烯/聚卡普隆组及聚酯/猪胶原蛋白组。于植入术后21天对粘连的范围与强度进行大体评估。结果 聚丙烯组因内脏粘连导致的损伤在统计学上更为显著（p值=0.002），且其粘连强度高于聚丙烯/聚卡普隆组与聚酯/猪胶原蛋白组（p值<0.001）；聚酯/猪胶原蛋白组的粘连强度较聚丙烯/聚卡普隆组更为严重（p值=0.035）。结论 采用聚丙烯网片行腹腔内植入修复腹壁缺损，会使其与腹腔内结构形成广泛且牢固的粘连；使用聚丙烯/聚卡普隆或聚酯/猪胶原蛋白型防粘连网片，可减少粘连的数量与严重程度。