Data from: Adaptive modulation of antibiotic resistance through intragenomic coevolution. Nature Ecology and Evolution

Figure_1_data Comma-separated files containing the data presented in Figure 1. conc = concentration antibiotic (μg/ml), od = Optical density (OD₆₀₀). Separate files for ampicillin (AMP), tetracycline (TET) and chloramphenicol (CML) in each host/plasmid combination (evo = evolved, anc = ancestral).<br>Figure_2_S2_S3_dataComma-separated file containing the data presented in Figure 2, Figure S2 and Figure S3. rep = replication, chrom = chromosome, pos1 = first genomic position of feature, ref = nucleotide in reference, evo = nucleotide in evolved, HGVS.c = variation within coding sequence, HGVS.p = variation within protein sequence.<br>Figure_S1_dataComma-separated file containing the data presented in Figure S1. rep = replication.<br>Figure_S4_dataComma-separated files containing the data presented in Figure S4. rep = replication, conc = concentration tetracycline (μg/ml), od = optical density (OD₆₀₀). Separate files for acrR, ompF and ychH knockouts.<br>Figure_S5_data Comma-separated file containing the data presented in Figure S5. rep = replication, rf = relative fitness of evolved strain vs ancestral plasmid free. Controls: ancestral plasmid containing vs ancestral plasmid free and ancestral plasmid free (GFP) vs ancestral plasmid free (mcherry).<br>Figure_S6_data Comma-separated file containing the data presented in Figure S6. rep = replication, plasmid (E = evolved, A = ancestral), host (E = evolved, A = ancestral), treatment = treatment evolved plasmid or host was sourced from. Columns there after are OD₆₀₀; column headers are seconds from start of growth curve.<br>Figure_S7_data Comma-separated file containing the data presented in Figure S7. rep = replication, rf = relative fitness of evolved strain with either ancestral plasmid (EA) or evolved strain with evolved plasmid (EE) vs ancestral plasmid containing. Control ancestral plasmid containing (GFP) vs ancestral plasmid containing (mcherry).<br>Figure_S8_data Comma-separated file containing the data presented in Figure S8. Clone = ID of randomly selected clone from transfer, transfer = number of transfers (days) from start of evolution experiment. ompF::IS N = not present, Y = present identified through PCR. tetA = mutations within tetA observed in ompF::IS background, tetR = mutations within tetR observed in ompF::IS background.<br>Population codes represent selection treatment: C - no antibiotic, A - ampicillin, T - tetracycline, AT - ampicillin + tetracycline, and A/T - cycling treatment.