Supplementary Material for: Differences in cognitive trajectories of dementia: Comparison Alzheimer’s disease dementia and Dementia with Lewy bodies in Korean patient cohort

Background and purpose:
Prediction of the dementia progression is important for patient management. We aimed to investigate the cognitive trajectories of Alzheimer’s disease dementia (ADD) and dementia with Lewy bodies (DLB) according to the initial structural change measured by comprehensive visual rating scales (CVRS).
Methods
We retrospectively included the patients who initially visited the Dementia Clinic of Chonnam National University Hospital between 2010 to 2012. All patients underwent dementia work up including neuropsychological battery (Seoul Neuropsychological Screening Battery, SNSB). We recruited the participant who underwent SNSB annually for three years successively. Total 136 patients of ADD and 63 patients of DLB were included for analyze. We analyzed the decline pattern of cognitive profile according to the initial brain structural changes.
Results
The general cognitive trajectories between ADD and DLB patients were not different. However, DLB patients showed more rapid decline of cognitive function in language and related function, visual memory function, and frontal executive function. The scores were lower in participants with DLB with lesser atrophy group in attention, visuospatial function, and frontal executive function. In analysis of the cognitive trajectories, the visual memory domain declined rapidly in DLB with lesser atrophy group compared with the ADD with lesser atrophy group.
Conclusion
We founded that the differences in visual cognitive profile in ADD and DLB patients in serial follow up of neuropsychological tests. It is prominent in the mild structural change group of ADD and DLB.

研究背景与目的：
痴呆病情进展预测对于患者的临床管理具有重要意义。本研究旨在基于全面视觉评定量表（comprehensive visual rating scales, CVRS）评估的初始脑结构变化，探究阿尔茨海默病痴呆（Alzheimer’s disease dementia, ADD）与路易体痴呆（dementia with Lewy bodies, DLB）患者的认知轨迹。

方法：
本研究回顾性纳入2010至2012年间首次就诊于全南大学医院痴呆门诊的患者。所有患者均接受痴呆相关评估，包括神经心理成套测验（首尔神经心理筛查量表，Seoul Neuropsychological Screening Battery, SNSB）。本研究招募了连续三年每年完成SNSB测评的受试者，最终共纳入136例ADD患者与63例DLB患者用于分析。我们基于初始脑结构变化，分析了认知特征的下降模式。

结果：
ADD与DLB患者的总体认知轨迹无显著差异。但DLB患者在语言及相关功能、视觉记忆功能与额叶执行功能方面的认知功能下降速度更快。脑萎缩程度较轻的DLB患者亚组在注意力、视空间功能与额叶执行功能方面的得分更低。在认知轨迹分析中，与脑萎缩程度较轻的ADD患者亚组相比，脑萎缩程度较轻的DLB患者亚组的视觉记忆域下降速度更快。

结论：
本研究发现，在系列随访神经心理测评中，ADD与DLB患者的视觉认知特征存在差异，且该差异在脑结构改变较轻的ADD与DLB患者亚组中尤为显著。