Electrophysiological properties of WT, PG6, and PA6 channels and their regulation by β2a and β3.

The values of V50 and k were calculated for each cell, then averaged. R values determined from test pulses to +20 mV. Data shown are mean±SEM from the number of cells shown in parentheses. Statistical significance of the β2a and β3 effects relative to either α1 alone (+α2δ1) were determined using ANOVA.†Currents from PG6 were completely inactivated by 350 ms, so the residual current at 25 ms (divided by peak) is reported (R25).§Current density was estimated from the peak of the I–V curve, and statistical significance was determined using Student's t-test.*P