Master transcriptional regulator SaeS in Staphylococcus aureus induces staphyloxanthin biosynthesis to promote survival during invasive infection

- Purpose: In this study, we discovered that saeS deletion attenuated STX biosynthesis by decreasing the expression of crt and rsb operon genes. We also investigated the effect of metal ions on S. aureus pathogenicity and the relationship between Zn and STX expression. Experiments using an S. aureus bloodstream infection mouse model revealed that SaeS was crucial for bacterial survival and that Zn supplementation weakened bacterial virulence and altered host immune defense mechanisms. - Nature of data: data type is numerical and quantitative. Data was collected from experiments. Data format is tabular. - Scope of the dataset: Data includes bacterial growth, virulence assay, CFU counting, mouse survival, and qRT-PCR results