Detection of continuous hierarchical heterogeneity by single-cell surface antigen analysis in the prognosis evaluation of acute myeloid leukaemia

In this study, we provided a CyTOF analysis pipeline to find out the AML heterogeneity dynamics along the pseudotime. Minute differences in temporal traits among samples could be exhibited on a trajectory, thus providing a new strategy for predicting AML relapse and monitoring drug responses over time scale. Here are mass cytometry datasets without pre-processing.

本研究构建了一套质谱流式细胞术 (CyTOF) 分析流程，用于解析急性髓系白血病 (Acute Myeloid Leukemia, AML) 沿拟时间的异质性动态变化特征。样本间细微的时间特征差异可在拟时间轨迹中得以呈现，由此为AML复发预测及跨时间尺度的药物响应监测提供了全新策略。本研究附带未经预处理的质谱流式数据集。