Genomic copy number aberrations in multiple synchronous lung cancer.. Homo sapiens

In current study, we applied array-CGH analysis to detect somatic copy number aberrations across tumor genome to help separate multiple primary lung cancers from metastasis cancers. Overall design: Genomic analysis was carried out in 15 lung adenocarcinomas and one regional lymph node metastasis from 6 patients with multiple synchronous lung cancer. WGS/WES was applied to profile the somatic mutations in each tumor, while array-CGH data was analyzed to screen somatic copy number changes.