Electromyographic assessment of swallowing different types of clinical disease, Parkinson's on and off phases

PURPOSE:to evaluate the electromyographic parameters of swallowing different types of clinical of idiopathic Parkinson disease on and off phases.METHODS:the study was performed at the Clinic of Neurology, Hospital of the Federal University of Pernambuco. The population of the study were 20 patients with Parkinson disease, divided by Unified Scale for Assessment of Parkinson's disease in three groups: tremor, akinetic-rigid and mixed. The surface electromyography examination was collected on suprahyoid muscles during swallowing and 3 ml water and 10 ml of yoghurt, which was repeated 5 times for each volume and consistency. This protocol was carried out before and after the medication period off and on.RESULTS:it was found that the phase off, akinetic-rigid group had the highest average in parts of swallows and duration of surface electromyography, while the mixed group had the lowest average amplitude. In phase on the three groups tended to improve or maintain the averages of the variables, but there was no significant difference between the clinical types, before or after Levodopa.CONCLUSION:drug therapy through Levodopa shows no consistent differences in surface electromyography of swallowing the clinical types of Parkinson disease.

研究目的：本研究旨在评估特发性帕金森病（idiopathic Parkinson disease）患者在服药关期与开期时，不同临床分型的吞咽肌电参数。
研究方法：本研究于伯南布哥联邦大学附属医院神经内科开展。共纳入20例帕金森病患者，依据统一帕金森病评定量表（Unified Scale for Assessment of Parkinson's disease）分为震颤型、运动迟缓-强直型及混合型三组。于舌骨上肌群（suprahyoid muscles）采集吞咽过程中的表面肌电图（surface electromyography）数据，受试物分别为3ml水与10ml酸奶，每种体积及稠度的受试物重复测定5次。该检测流程分别在患者服药关期与开期的用药前后完成。
研究结果：结果显示，在服药关期，运动迟缓-强直型组的吞咽动作时长及表面肌电信号持续时间的平均值最高，而混合型组的平均肌电幅值最低。在服药开期，三组的各项变量平均值均有所改善或维持稳定，但无论左旋多巴（Levodopa）用药前后，各临床分型间均无显著差异。
研究结论：左旋多巴药物治疗并未在不同临床分型的帕金森病患者吞咽肌电图检测中体现出一致性差异。