NPRC deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in ApoE knockout mice
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE233428
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ApoE-/-mice were fed chow or Western diet for 12 weeks and NPRC expression was significantly increased in the aortic tissues of Western diet-fed mice. Systemic NPRC knockout mice were crossed with ApoE-/- mice to generate ApoE-/-NPRC-/- mice, and NPRC deletion resulted in a significant decrease in the size and instability of aortic atherosclerotic lesions in ApoE-/-NPRC-/- versus ApoE-/- mice. aortas from 5 ApoE-/- mice and 3 ApoE-/-NPRC-/- were subjected to RNA sequencing
创建时间：
2023-07-04
