PDGFRA-G680R mutant kinase domain in complex with a 6,7-bis(2-methoxyethoxy)quinazoline-based compound (44)

PDGFRA-G680R mutant kinase domain in complex with a 6,7-bis(2-methoxyethoxy)quinazoline-based compound (44) Descriptor: (1~{S})-1-[2-[4-[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]piperazin-1-yl]pyrimidin-5-yl]-1-(4-fluorophenyl)ethanamine, Platelet-derived growth factor receptor alpha Authors: Scrima, A, Mueller, M.P, Rauh, D. Deposit date: 2025-11-27 Release date: 2026-07-15 Last modified: 2026-08-19 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure-based scaffold hopping reveals strategies to overcome oncogenic KIT and PDGFRA mutation-driven drug-resistance in GIST. Nat Commun, 17, 2026