Chitosan/NaF Particles Prepared Via Ionotropic Gelation: Evaluation of Particles Size and Morphology

The aim of this work was to perform an analysis of the influence of Sodium Fluoride (NaF) on chitosan particles size and morphology produced via ionotropic gelation with higher rotational stirring speed. Samples were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Dynamic Light Scattering (DLS), Zeta Potential (ζ), Scanning Electron Microscopy and Energy Dispersive Spectroscopy (SEM/EDS). Chitosan/TPP particles diameter obtained was in the order of 3.8 µm. When NaF was added in different concentration (0.05%, 0.2% and 2%), the particle size diameter values, Zeta Potential and Poly Dispersive Index measures consequently decreased. Even so, no further modification in morphology was found. An exception was made for the samples with higher NaF concentration. After 21 days, occurred an increase in the particle size diameter. In the future, the proposed methodology could provide a dentistry application, especially on delivering particles of NaF.

本研究旨在分析氟化钠（Sodium Fluoride, NaF）对采用高旋转搅拌速率的离子凝胶法制备的壳聚糖颗粒的粒径与形貌的影响。研究采用傅里叶变换红外光谱（Fourier Transform Infrared Spectroscopy, FTIR）、动态光散射（Dynamic Light Scattering, DLS）、Zeta电位（Zeta Potential, ζ）、扫描电子显微镜-能谱联用（Scanning Electron Microscopy and Energy Dispersive Spectroscopy, SEM/EDS）对样品进行表征。结果表明，所得壳聚糖/TPP颗粒直径约为3.8 μm。当以0.05%、0.2%及2%的不同浓度添加氟化钠时，颗粒粒径、Zeta电位及多分散指数均随之降低。尽管整体未观察到形貌发生明显变化，但高浓度氟化钠样品属于例外。21天后，颗粒粒径出现增大。未来，本研究提出的制备方法可应用于牙科领域，尤其可用于递送氟化钠颗粒。