Novel RNA biomarkers in urine and plasma of patients with prostate cancer.

Current prostate cancer diagnostic tests suffer from insufficient sensitivity and specificity. Novel biomarkers that can be detected by minimally invasive methods are of a particular value. This study was aimed at screening for candidate RNA biomarkers of prostate cancer. To that end, we performed whole transcriptome profiling of urine and plasma of patients with prostate cancer by RNA-Seq. Samples obtained from patients with benign prostatic hyperplasia were used as a control group to ensure high specificity of identified biomarkers.