Effect of depletion of transcription factors Sp1 and Sp3 on gene expression of primary MLECs (mouse endothelial lung cells)

To investigate the function of transcription factors Sp1 and Sp3 in the regulation of endothelial functions, we established tamoxifen-induced endothelial Sp1/Sp3 knockout mice and isolated the MLECs We then performed gene expression profiling analysis using data obtained from RNA-seq of MLECs from endothelial Sp1/Sp3 knockout mice and their control mice Overall design: Comparative gene expression profiling analysis of RNA-seq data for MLECs from endothelial Sp1/Sp3 knockout mice and their control mice