Outcome anti-HBs level and anti-HBc status adjusted for covariates for 1^st screen and replicated data

Key: GMTratio: Geometric mean peak anti-HBs titer adjusted for covariates. OR: odds ratio adjusted for covariates. 95%CI: 95% Confidence intervals. The results shown represent single SNP models adjusted for covariates with associations of GMTratio/OR of <0.6 or >1.5 and P≤0.001 level (for other markers taken forward to 2nd screen see Supplementary Table S2). The genotype designation are 1 for ancestral and 2 for variant allele; _33 indicates the grouping of homozygote variants (22) and heterozygotes (12). Multi-marker models affecting peak anti-HBs level at these cut-off values were MAPK8, IL10RA and IFNG. CD163 was correlated with anti-HBc status in the multi-SNP analysis. For all other genes the multi-marker models indicated a comparable modification of GMT, but with reduced significance compared to single SNP models (data not shown), except for the CD163 anti-HBc model (see below). The association of ITGAL s595 (rs2230433) with anti-HBs level was replicated. SNPs s321 and s574 were out of HWE at the P<0.05 level. aCD163 multi-SNP model for anti-HBc: s503_12 GMTratio 3.89, P = 0.006, 95%CI 1.5–10.1; s503_22 GMTratio 7.24, P = 2.31E-04, 95%CI 2.5–20.75; s504_12 GMTratio 1.74, P = 0.091, 95%CI 0.9–3.30; s504_22 GMTratio 4.53, P = 0.009, 95%CI 1.5–14.1 bGenotypes 2nd screen: s594_11 = 170 s594_12 = 113 s594_22 = 24; s595_11 = 146 s595_12 = 165 s595_22 = 50.