Richter transfromation of chronic lymphocytic leukemia driven by Epstein-Barr virus reactivation during therapy-realted immunosuppression

Gene expression analysis in Epstein-Barr virus negative DLBCL samples obtained from patients with Richter syndrome, lymphocytes from CLL patients and epstein-Barr virus positive DLBCL cell lines derived after CLL tumors xenotransplantation Gene expression profiling was conducted in EBV+DLBCL xenograft derived cell lines, in tumor samples from patients with EBV- DLBCL (Richter syndrome) and non-transformed CLL samples using Affymetrix Human Gene ST 1.0 microarrays..