5-Formylcytosine Landscapes of Human Preimplantation Embryos at Single-cell Resolution
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
The epigenetic regulation containing DNA methylation and chromatin accessibility have been extensively explored in human preimplantation development. However, the dynamic of demethylation in this crucial process remains largely unknown. In this study, we use CLEVER-seq to quantify the DNA 5-formylcytosine (5fC) level of human early embryos. The distribution of 5fC exhibits genomic region preference and are enriched in L1 and ERVK, subfamily of repeat element. Unlike in mice, the paired pronuclei presents inconsistent 5fC level although the male pronuclei experiences stronger demethylation. And the centre of 5fC shows less accessible genome especially in proximal region. Collectively, our work offers new insight into the understanding of the complex demethylation in early human embryo development.
提供机构：
Southern Medical University
创建时间：
2022-02-20
