Analyzing the effect of Susabinori lipid (SNL) on the hepatic transcriptome of db/db mice by RNA-Seq. Mus musculus

We have demonstrated the impact of lipids extracted from the marine red alga Susabinori (Pyropia yezoensis) in a murine model of type 2-diabete (db/db). Feeding Susabinori lipids (SNL) protected against obesity-induced hepatic steatosis in db/db mice [Yanagita, T., et al. Arch Biochem Biophys. 691: 108486 (2020)]. In this project, we conducted RNA-Seq analysis of the hepatic transcriptome to understand the specific genes or biological pathways underlying the effects of SNL. We performed the comparative analysis of differentially expressed genes between normal mice and db/db mice consuming a control diet, as well as SNL-fed db/db mice.