Undetected cancer in clinical prostate biopsies

This dataset comprises digitized benign prostate hematoxilyn and eosin (H&E) biopsies from men with raised prostate-specific antigen (PSA) values. The biopsies were systematically taken from different locations in the prostate and were not guided by magnetic resonance imaging (MRI). The dataset includes paired samples from patients with comparable age and PSA levels, all initially diagnosed as benign but with different outcomes upon subsequent follow-ups and re-biopsies. While some patients remained cancer-free during eight years of follow-up, others were diagnosed with prostate cancer within the subsequent 30 months of follow-up. The final processed dataset includes 213 patients from northern Sweden, resulting in a total of 587 H&E prostate needle biopsies. Among these, 125 control patients with 333 biopsies exhibited no cancer development in eight years following the initial diagnosis. Conversely, 88 case patients with 254 biopsies were diagnosed with prostate cancer of various ISUP grades within the 30 months following the initial diagnosis. Each case patient is accompanied by one to three control patients, paired for similar age, PSA value and year of diagnosis. Patients were anonymized by assigning random case IDs and MRXS image files were anonymized by using the module in https://github.com/bgilbert/anonymize-slide.本数据集包含来自前列腺特异性抗原（PSA）水平升高男性的数字化良性前列腺苏木精-伊红（H&E）活检样本。这些活检样本采用系统方式取自前列腺的不同部位，未使用磁共振成像（MRI）进行定位引导。本数据集涵盖年龄与PSA水平匹配的患者配对样本，所有样本最初均被诊断为良性，但在后续随访与再次活检中呈现出不同的结局：部分患者在8年随访期间未发生癌变，另有部分患者在初始诊断后的30个月随访期内被确诊为前列腺癌。 经最终处理后的数据集涵盖来自瑞典北部的213名患者，共计包含587例前列腺穿刺H&E活检样本。其中125名对照组患者（共333例活检样本）在初始诊断后的8年随访期间未检测出癌变；与之相对，88名病例组患者（共254例活检样本）在初始诊断后的30个月随访期内被确诊为不同ISUP分级的前列腺癌。每一名病例组患者均匹配1至3名对照组患者，匹配标准为年龄、PSA水平与诊断年份相近。 所有患者均通过分配随机病例ID进行匿名化处理，MRXS图像文件则通过使用https://github.com/bgilbert/anonymize-slide中的模块完成匿名化。